Job Title: Scientist
Duration: 12 Months
Location: Boston, MA 02115
Qualifications:
We are seeking an exceptional Scientist in the Boston Discovery Biologics group, with the primary responsibility to execute cell-based binding and functional assays. The qualified candidate will be a scientist with core capabilities in cell culture, automation and high-throughput cell-based assay execution and statistical data analysis in the quest to discover innovative large molecule therapeutics. They should have deep expertise in cell technologies, dose-response relationship and using proper statistical tools for data analysis and interpretation. The ideal candidate will have first-hand knowledge of aseptic technique in cell culture including subculturing and cryopreservation of cells, flow cytometry sample preparation, reporter gene assay configuration, data acquisition, analysis, and reporting.
• M.S. in pharmacology, immunology, biotechnology or biology, with 1+ years or B.S. with 3+ years of relevant in vitro, cell-based assay experience, preferably in a pharmaceutical/ biotechnology setting. Highly relevant lab experience through degree program can be considered.
• Excellent communication and collaboration skills
Required skills:
• Hands-on experience with mammalian cell culture, flow cytometry and related data analysis.
• ELISA and other immunological assay skills are desired.
• Working knowledge using standard data analysis tools such as FlowJo, Graph Pad Prism and Microsoft programs.
• Familiarity with automated liquid handling systems, robotics, and high-throughput cell-based assays screening formats.
• Ability to multi-task with highly analytical mind, attention to details, and organizational skills are critical.
• Excellent written and interpersonal communication skills and the ability to collate the results and make a presentation to the stakeholders.
• The ability to work independently, as well as collaboratively with peers within and across departments is expected.
• Champion for diverse and inclusive culture
Preferred skills:
• Experience in assay development in a wide range of cellular and biochemical assays such as reporter gene assays, Ab internalization assay, enzymatic activity assays, etc.
• Experience with developing high throughput methods into workflows (e.g. Hamilton and/or Agilent Bravo automated liquid handling platform, Thermo Scientific Momentum workflow scheduling software, etc.)
• Experience working with T cell engagers.
Note:
• Onsite role.
• No PHD.
Responsibilities:
Cell-Based Assay Scientist, Discovery Biologics
We are on a quest for cures and are committed to be the world’s premier, most research-intensive biopharmaceutical company. Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines.
Your role at our company is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At our company, we’re inventing for life.
We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively for the common good. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.
What you will do:
• Contribute to the binding and functional characterization of therapeutic molecules via cellular and/or biochemical assays.
• Implement assay automation to screen drug candidates in early discovery pipelines.
• Plan, design, execute and troubleshoot in vitro pharmacological experiments to support and advance drug discovery programs.
• Maintain timely, accurate laboratory records of activities & comply with good documentation practices.
• Effectively collaborate with integrated teams in a matrix organization setting to facilitate the conduct of studies and to the success of discovery programs.
Must haves:
• Cell culture- Mammalian cell culture
• Flow cytometry experience- 2 colors
• Should be able to work with OEB 4 Compounds if/when needed. PPE will be provided, and additional safety training will be provided
• Experience working with antibodies, cells in BSL-2 lab.
• Experience with ELISA
• Experience with Immunohistochemistry
• Experience with Sterile technique/aseptic technique
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